谢努力，副教授。湖南大学博士，上海交通大学博士后（博后导师：樊春海院士）。博士期间获得国家奖学金、校长奖学金等荣誉，曾获国家留学基金委（CSC）公派奖学金资助，赴University of Michigan安娜堡分校以联合培养博士研究生的身份交流学习2年。博士后期间获得上海市”超级博士后“激励计划资助。现为中国化学会会员，芙蓉计划卫生健康高层次人才，湖南省生物医学工程学会纳米医学与工程专委委员，《Exploration》期刊青年编委。主要从事核酸纳米技术在分子计算、疾病诊断、新型药物递送和疾病治疗等领域研究，以第一作者/通讯作者在Nature(二作)、JACS、Angew. Chem. Int. Ed.、ACS Nano、Adv. Sci.、Nano lett.、Chem. Sci.、Anal. Chem.、Chem. Commun.等国际知名期刊发表论文数十篇，其中一作论文10余篇， 论文总引次数达 2200次以上，H-index为22。
参与《药剂学》、《药物分析》、《药剂学实验》等课程教学活动，曾获bv1946伟德官网教学质量优秀奖（本科），指导学生获得湖南省省级大学生创新训练项目1项。
主持国家自然科学基金青年项目 、湖南省自然科学基金青年项目 ，国家重点实验室开放基金 ，bv1946伟德官网科研启动项目等科研项目。参与国家自然科学基金重点项目、面上项目多项。
ORCID: https://orcid.org/0000-0002-8846-0532
研究方向及兴趣：
1、基于DNA自组装纳米结构的智能药物递送
2、DNA分子计算在癌症和其他疾病上的智能、精准诊断应用
3、核酸与金属相结合的纳米材料制备及其皮肤相关疾病的治疗
热忱欢迎具有药学、化学、化学生物学等学科背景的研究生或本科生加入研究团队。
主要论文：
1. Hanane Aliouat, Detian Zhang, Lanyuan Peng, Jiaxin Huang, Hongshi Cheng, Jiaojiao Zhu, Xiang Chen, Nuli Xie*, Wenhu Zhou*, Shuang Zhao*. Targeted DNA Nanomachine Enables Specific miRNA-Responsive Singlet Oxygen Amplification for Precise Cutaneous Squamous Cancer Therapy. Adv. Sci, 2025, DOI: 10.1002/advs.202415296.
2. Shiyuan Liu, Jiaoli Wang, Yu Chen, Jiahao Fan, Bin Du, Ruiting Liu, Xiaobei Zhu, Kemin Wang, Nuli Xie*, Jin Huang*. Modular Assembled Localized Hybridization Chain Reaction for In Situ mRNA Amplified Imaging [J]. Nano. Lett., 2024, 24, 37, 11590–11598.
3. Jing Wang, Nuli Xie, Shan Lu, Bo Xiao, Yangqin Ou, Qingnian Li, Dexian Liu, Wenhu Zhou*. CpG and Rutin Co‐Loaded DNA Tetrahedra for Targeted Therapy of Intracerebral Hemorrhage: Synergistic Hematoma Clearance and Neuroinflammation Inhibition. Adv. Funct. Matter. 2024, DOI:10.1002/adfm.202403469.
4. Hui Lv, Nuli Xie, Mingqiang Li, Mingkai Dong, Jiang Li, Xiaolei Zuo, Haibo Chen, Fei Wang*, Chunhai Fan*. Large-scale reconfigurable DNA-based logic gate for complex DNA computing. Nature 2023, 622, 292-300. (SCI一区)
5. Zhenxiang Liu#, Nuli Xie#, Juan Li, Xiaoxiao Fu, Kemin Wang, Hui Shi*, Jin Huang*. Self-Priming DNA Polymerization-Propelled Stochastic Walkers on Magnetic Microbeads for Amplified Detection of miRNA. Anal. Chem. 2022, 95, 9, 4529-4535. (SCI一区)
6. Nuli Xie, Huimin Wang, Xiaoxiao Fu, Jiaoli Wang, Jing Li, Kemin Wang, Jin Huang*. Dual amplification of bio-barcode and auto-cycling primer extension for highly sensitive detection of miRNA. Chem. Commun. 2022, 58, 73, 10221-10224. (SCI一区)
7. Nuli Xie, Mingqiang Li, Yue Wang, Hui Lv, Jiye Shi, Jiang Li, Qian Li, Fei Wang*, Chunhai Fan. Scaling up multi-bit DNA full adder circuits with minimal strand displacement reactions. J. Am. Chem. Soc. 2022, DOI: 10.1021/jacs.2c03258. (SCI一区)
8. Nuli Xie, Shiyuan Liu, Hongmei Fang, Yanjing Yang, Ke Quan, Jing Li, Xiaohai Yang, Kemin Wang, Jin Huang*. Three-dimensional molecular transfer from DNA nanocages to inner gold nanoparticle surfaces. ACS Nano 2019, 13, 4174-4182. (SCI一区)
9. Nuli Xie, Haiyan Wang, Ke Quan, Feng Feng, Jin Huang*, Kemin Wang*. Self-assembled DNA-Based geometric polyhedrons: construction and applications. TrAC-Trends in Anal. Chem. 2020, 126, 115844. (SCI一区)
10. Nuli Xie, Jin Huang*, Xiaohai Yang, Xiaoxiao He, Jianbo Liu, Jiaqi Huang, Hongmei Fang, Kemin Wang*. Scallop-inspired DNA nanomachine: a ratiometric nanothermometer for intracellular temperature sensing. Anal. Chem. 2017, 89, 12115-12122. (SCI一区)
11. Nuli Xie, Jin Huang*, Xiaohai Yang, Yanjing Yang, Ke Quan, Min Ou, Hongmei Fang, Kemin Wang*. Competition-mediated FRET-switching DNA tetrahedron molecular beacon for intracellular molecular detection. ACS Sens. 2016, 12, 1445-1452. (SCI一区)
12. Nuli Xie, Jin Huang*, Xiaohai Yang, Yanjing Yang, Ke Quan, He Wang, Le Ying, Min Ou, Kemin Wang*. A DNA tetrahedron-based molecular beacon for tumor-related mRNA detection in living cells. Chem. Commun. 2016, 52, 2346-2349. (SCI一区)
13. Nuli Xie, Shiyuan Liu, Xiaohai Yang, Xiaoxiao He, Jin Huang*, Kemin Wang*. DNA tetrahedron nanostructures for biological applications: biosensors and drug delivery. Analyst 2017, 142, 3322-3332. (SCI二区)
14. Le Ying #, Nuli Xie#, Yanjing Yang, Xiaohai Yang, Qifeng Zhou, Bincheng Yin, Jin Huang*, Kemin Wang*. A cell-surface-anchored ratiometric i-motif sensor for extracellular pH detection. Chem. Commun. 2016, 52, 7818-7821. (SCI一区)
15. Hongmei Fang#, Nuli Xie#, Min Ou, Jin Huang, Wenshan Li, Qing Wang, Jianbo Liu, Xiaohai Yang*, Kemin Wang*. Detection of nucleic acids in complex samples via magnetic microbead-assisted catalyzed hairpin assembly and “DD-A” FRET. Anal. Chem. 2018, 90, 7164-7170. (SCI一区)
